Key result
Mean glycated albumin levels were significantly associated with the progression of diabetic nephropathy (OR 2.03) in subjects with type 1 diabetes, whereas mean HbA1c was not.
Why the study?
Do glycated albumin levels predict the progression of diabetic nephropathy and carotid artery atherosclerosis better than HbA1c in subjects with type 1 diabetes?
Population
154 subjects with type 1 diabetes who had regularly measured urine albumin-creatinine ratios, estimated…
Design
Cohort
Follow-up
median 2.8 years
Authors
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Glycated albumin may aid nephropathy risk stratification in type 1 diabetes; leaves open whether it should replace HbA1c monitoring.
Cohort (n=154)
No
Do glycated albumin levels predict the progression of diabetic nephropathy and carotid artery atherosclerosis better than HbA1c in subjects with type 1 diabetes?
Odds Ratio: 2.03 (95% CI 1.27–3.26)
p-value: p=0.003
In subjects with type 1 diabetes, mean glycated albumin levels are a better predictor of diabetic nephropathy progression than HbA1c, though neither predicts carotid atherosclerosis progression.
Yoon et al. (2015) conducted a cohort in Type 1 Diabetes (n=154). Mean glycated albumin (GA) levels vs. Mean HbA1c levels was evaluated on Progression of diabetic nephropathy (OR 2.03, 95% CI 1.27-3.26, p=0.003). Mean glycated albumin levels were significantly associated with the progression of diabetic nephropathy (OR 2.03) in subjects with type 1 diabetes, whereas mean HbA1c was not.
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