Key result
Both HbA1c (OR 2.630; 95% CI 1.401-4.935; P=0.003) and glycated albumin (OR 1.215; 95% CI 1.008-1.466; P=0.041) were independent risk factors for increased carotid intima-media thickness.
Why the study?
Are higher levels of HbA1c and glycated albumin associated with increased subclinical atherosclerosis in patients with impaired glucose regulation?
Cross-Sectional (n=640)
Are higher levels of HbA1c and glycated albumin associated with increased subclinical atherosclerosis in patients with impaired glucose regulation?
Odds Ratio: 2.63 (95% CI 1.401–4.935)
p-value: p=0.003
In a Chinese population with impaired glucose regulation, both HbA1c and glycated albumin are independently associated with subclinical atherosclerosis as measured by carotid intima-media thickness.
Supports glycemic markers for subclinical atherosclerosis assessment in impaired glucose regulation; hypothesis-generating pending longitudinal confirmation.
The aim of this study was to investigate the correlations of glycated haemoglobin A1c (HbA1c) and glycated albumin (GA) with subclinical atherosclerosis in middle-aged and elderly Chinese populations with impaired glucose regulation (IGR). In total, 640 subjects with IGR and no history of cardiovascular disease or carotid artery plaque were recruited for this study (256 men, 384 women; age range, 40-70 years). The carotid intima-media thickness (C-IMT) measured by carotid ultrasonography was used as an indicator of subclinical atherosclerosis. Increased C-IMT was defined as ≥ 0.70 mm (upper quartile). HbA1c and GA were measured with high-performance liquid chromatography and enzymatic method, respectively. The average HbA1c and GA among all 640 subjects were 5.7 ± 0.3% and 14.0 ± 1.1%, respectively. HbA1c and GA were higher in subjects with increased C-IMT than in subjects with normal C-IMT (5.8 ± 0.3% vs 5.7 ± 0.3% and 14.2 ± 1.0% vs 13.9 ± 1.1%, respectively; both P < 0.01). Correlation analysis showed that both HbA1c and GA were positively correlated with C-IMT (r = 0.135 and 0.112, respectively; both P < 0.01). Logistic regression analysis revealed that both HbA1c (odds ratio (OR), 2.630; 95% confidence interval (95% CI), 1.401-4.935; P = 0.003) and GA OR, 1.215; 95% CI, 1.008-1.466; P = 0.041) were independent risk factors for increased C-IMT. Both HbA1c and GA reflect the risk of subclinical atherosclerosis in middle-aged and elderly Chinese populations with IGR.
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Ma et al. (2015) conducted a cross-sectional in impaired glucose regulation (n=640). Glycated haemoglobin A1c (HbA1c) and glycated albumin (GA) was evaluated on increased carotid intima-media thickness (≥ 0.70 mm) (OR 2.630, 95% CI 1.401-4.935, p=0.003). Both HbA1c (OR 2.630; 95% CI 1.401-4.935; P=0.003) and glycated albumin (OR 1.215; 95% CI 1.008-1.466; P=0.041) were independent risk factors for increased carotid intima-media thickness.
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