Key result
In guinea-pig ventricular myocytes, potentiation by voltage-clamp pulses reversibly increased subsarcolemmal sodium concentration within 20 nm of the sarcolemma from 17 +/- 5 mM to 40 +/- 7 mM.
Population
Guinea-pig ventricular myocytes
Comparison
Electrical stimulation vs Unstimulated cells
Design
Preclinical
Authors
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Does not alter clinical sodium management; leaves open microdomain Na+ dynamics for future in vivo validation.
Absolute Event Rate: 40% vs 17%
Electrical stimulation of ventricular myocytes causes significant, highly localized subsarcolemmal sodium accumulation and microheterogeneity, which may simultaneously regulate different ion channels and exchangers.
Wendt-Gallitelli et al. (1993) studied Guinea-pig ventricular myocytes. Potentiation by trains of paired voltage-clamp pulses vs. Unstimulated cells was evaluated on Subsarcolemmal sodium concentration (sigma Na20nm). In guinea-pig ventricular myocytes, potentiation by voltage-clamp pulses reversibly increased subsarcolemmal sodium concentration within 20 nm of the sarcolemma from 17 +/- 5 mM to 40 +/- 7 mM.
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