Key result
Hypertriglyceridemia accounts for 10% to 20% of acute pancreatitis cases in China and is associated with significantly higher complication rates and severity compared to other etiologies.
Why the study?
The incidence of hypertriglyceridemia-induced acute pancreatitis is rising worldwide and carries higher complication rates and severity than other etiologies, prompting a review of clinical and basic research evidence.
This narrative review highlights that hypertriglyceridemia-induced acute pancreatitis is rising in incidence and is associated with higher complication rates, requiring specific management to lower serum triglycerides alongside standard supportive care.
May warrant etiology-specific vigilance in acute pancreatitis; leaves open optimal management strategies pending prospective trials.
Hypertriglyceridemia (HTG) is the third most common cause of acute pancreatitis (AP), and the incidence of HTG-induced AP (HTG-AP) is rising worldwide as a result of changes in lifestyle and dietary habits. In China, HTG accounts for 10% to 20% of the causes of AP, even becoming the second leading cause of AP. The presentation and diagnosis of HTG-AP is similar to that of AP from other causes, however, the complication rates and severe AP are significantly higher in patients with HTG-AP than in patients with other etiologies. Regarding the management of HTG-AP, the initial management is similar to that of AP from other causes and mainly includes fluid resuscitation, pain control, and nutritional support. In addition to supportive care, it is necessary to take appropriate measures to decrease serum TG levels, in order to alleviate the progression of AP and prevent recurrence. This review aims to summarize existing clinical and basic research evidence of HTG-AP and seeks to highlight the epidemiology, definition, pathogenesis, clinical course, diagnosis, management, prevention of recurrence, and specific clinical scenarios, such as HTG-AP during pregnancy, HTG-AP with diabetic ketoacidosis.
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Gao et al. (2023) conducted a review in Hypertriglyceridemia-induced acute pancreatitis. Hypertriglyceridemia vs. Other etiologies of acute pancreatitis was evaluated. Hypertriglyceridemia accounts for 10% to 20% of acute pancreatitis cases in China and is associated with significantly higher complication rates and severity compared to other etiologies.
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