Key result
Patients with resistant hypertension had a significantly higher neutrophil to lymphocyte ratio compared to those with controlled hypertension (P=0.03) and normotension (P<0.001).
Why the study?
Is the neutrophil/lymphocyte ratio (NLR) elevated in patients with resistant hypertension compared to those with controlled hypertension or normotension?
Observational (n=150)
Is the neutrophil/lymphocyte ratio (NLR) elevated in patients with resistant hypertension compared to those with controlled hypertension or normotension?
p-value: p=<.001
Neutrophil to lymphocyte ratio is significantly elevated in patients with resistant hypertension compared to those with controlled hypertension or normotension, suggesting a potential role for inflammation in blood pressure control.
May reflect inflammation in resistant hypertension; hypothesis-generating and should not yet change practice.
Resistant hypertension (RHT) is an important disease that causes an increase in cardiovascular risk, yet its etiology remains unclear. The authors aimed to investigate neutrophil/lymphocyte ratio (NLR) as an inflammation marker in patients with RHT. A total of 150 patients were included in the study and grouped according to their office and ambulatory blood pressure measurements. They were classified as having normotension (NT), controlled hypertension (CHT), or RHT. The RHT group had a significantly higher NLR than the CHT group (P=.03), and NLRs of both hypertension groups were significantly higher than those in the NT group (P<.001, for both). NLR and neutrophil count were found to be independent correlates for RHT in multivariate analysis (P<.001). NLR and neutrophil count are increased in RHT patients than both CHT and NT patients. This finding, which is defined for the first time in patients with RHT, may imply the importance of inflammation in blood pressure control.
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Belen et al. (2015) conducted an observational in Resistant hypertension (n=150). Resistant hypertension vs. Controlled hypertension and normotension was evaluated on Neutrophil/lymphocyte ratio (NLR) (p=<.001). Patients with resistant hypertension had a significantly higher neutrophil to lymphocyte ratio compared to those with controlled hypertension (P=0.03) and normotension (P<0.001).
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