Key result
Loss of Myosin VI function in Drosophila larvae significantly decreased locomotor activity, reduced neuromuscular junction length, and altered synaptic vesicle localization.
Absolute Event Rate: 1.36% vs 5.16%
p-value: p=<0.0001
Myosin VI is important for proper synaptic function and morphology at the Drosophila neuromuscular junction.
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Myosin VI's NMJ role in Drosophila leaves open relevance to human synapses; warrants mammalian validation before clinical consideration.
Kisiel et al. (2011) studied Myosin VI loss of function. Loss of function jaguar (jar) alleles (Myosin VI mutation) vs. Wild-type control was evaluated on Larval path length over 5 minutes on nutritive substance (cm) (p=<0.0001). Loss of Myosin VI function in Drosophila larvae significantly decreased locomotor activity, reduced neuromuscular junction length, and altered synaptic vesicle localization.
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