Key result
Selective genetic ablation of Zfp423 in visceral adipose precursors induced browning of visceral white adipose tissue, improving cold tolerance and reversing insulin resistance in obese mice.
Why the study?
Does selective genetic ablation of Zfp423 in visceral adipose precursors improve insulin sensitivity in obese mice?
Does selective genetic ablation of Zfp423 in visceral adipose precursors improve insulin sensitivity in obese mice?
Directing visceral white adipocyte precursors to a thermogenic fate via Zfp423 deletion improves cold tolerance and reverses insulin resistance in obese mice.
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Remains preclinical without clinical implications; leaves open whether Zfp42 targeting improves metabolic outcomes in human obesity.
Hepler et al. (2017) studied Obesity and insulin resistance. Selective genetic ablation of Zfp423 was evaluated on Accumulation of beige-like thermogenic adipocytes, cold tolerance, and insulin resistance. Selective genetic ablation of Zfp423 in visceral adipose precursors induced browning of visceral white adipose tissue, improving cold tolerance and reversing insulin resistance in obese mice.
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