Key result
Icariin dose-dependently reversed cardiac morphometric and haemodynamic changes and attenuated myocardial apoptosis and MMP-2/9 activity in rats with isoproterenol-induced heart failure.
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Supports icariin investigation in experimental HF; leaves open clinical translation and human relevance.
Song et al. (2011) studied Congestive heart failure. Icariin vs. Control (isoproterenol-induced heart failure without icariin) was evaluated on Cardiac morphometric and haemodynamic parameters, MMP activity, and myocardial apoptosis. Icariin dose-dependently reversed cardiac morphometric and haemodynamic changes and attenuated myocardial apoptosis and MMP-2/9 activity in rats with isoproterenol-induced heart failure.
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