Obesity was associated with a significantly higher mean platelet volume compared to non-obese controls (10.3 ± 1.2 vs. 9.0 ± 0.8 fl, p < 0.01).
Case-Control (n=200)
Does obesity increase mean platelet volume compared to non-obese controls?
Mean platelet volume is significantly elevated in patients with obesity and correlates with BMI, suggesting a potential mechanism for their increased cardiovascular risk.
Absolute Event Rate: 10.3% vs 9%
p-value: p=<0.01
Mean platelet volume (MPV), a determinant of platelet function, is a newly emerging risk factor for atherothrombosis. The present study was designed to evaluate MPV in patients with obesity compared with non-obese control subjects. We selected 100 non-obese subjects and 100 subjects with obesity body mass index (BMI) > or =30 kg/m(2) matched for age and gender. The MPV was significantly higher in obese group than in non-obese control group (10.3 +/- 1.2 vs. 9.0 +/- 0.8 fl, p < 0.01). MPV was positively correlated with BMI in obese group (p < 0.05). Increased MPV may be a possible cause for increased cardiovascular risk in patients with obesity.
Çoban et al. (Thu,) conducted a case-control in Obesity (n=200). Obesity vs. Non-obese subjects was evaluated on Mean platelet volume (MPV) (p=<0.01). Obesity was associated with a significantly higher mean platelet volume compared to non-obese controls (10.3 ± 1.2 vs. 9.0 ± 0.8 fl, p < 0.01).