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November 1, 1996Critical Care Medicine

Prospective, randomized trial of two antiseptic solutions for prevention of central venous or arterial catheter colonization and infection in intensive care unit patients

Olivier Mimoz Laurence Piéroni Christine Lawrence Alain Edouard Yannick Costa Kamran Samii Christian Brun‐Buisson

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Key Points

To compare the efficacy of two antiseptic solutions in preventing catheter-related infections.
Prospective, randomized clinical trial in a surgical-trauma ICU
Patients assigned to chlorhexidine or povidone iodine for catheter care
Catheter tips cultured for infection diagnosis at specific intervals
Chlorhexidine group had significantly lower catheter colonization (12 vs. 31, RR 0.4, p < .01)
Reduced rate of central venous catheter-related sepsis in chlorhexidine group (5 vs. 19, RR 0.3, p = .02)
Superior prevention of Gram-positive infections with chlorhexidine (5 vs. 20, p < .001)

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Implication

Randomized trial compares antiseptics for preventing catheter infections in ICU patients, suggesting efficacy differences.

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Cite This Study

Mimoz et al. (1996) studied this question.

synapsesocial.com/papers/6a626d2db8617574e1f57390 https://doi.org/10.1097/00003246-199611000-00010

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Synapse has enriched 10 related papers. Consider them for comparative context:

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