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November 1, 1996Critical Care Medicine

Prospective, randomized trial of two antiseptic solutions for prevention of central venous or arterial catheter colonization and infection in intensive care unit patients

Olivier Mimoz Laurence Piéroni Christine Lawrence Alain Edouard Yannick Costa Kamran Samii Christian Brun‐Buisson

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Key Points

To compare the efficacy of two antiseptic solutions in preventing catheter-related infections.
Prospective, randomized clinical trial in a surgical-trauma ICU
Patients assigned to chlorhexidine or povidone iodine for catheter care
Catheter tips cultured for infection diagnosis at specific intervals
Chlorhexidine group had significantly lower catheter colonization (12 vs. 31, RR 0.4, p < .01)
Reduced rate of central venous catheter-related sepsis in chlorhexidine group (5 vs. 19, RR 0.3, p = .02)
Superior prevention of Gram-positive infections with chlorhexidine (5 vs. 20, p < .001)

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Implication

Randomized trial compares antiseptics for preventing catheter infections in ICU patients, suggesting efficacy differences.

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Cite This Study

Mimoz et al. (1996) studied this question.

synapsesocial.com/papers/6a626d2db8617574e1f57390 https://doi.org/10.1097/00003246-199611000-00010

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Chlorhexidine Compared with Povidone-Iodine Solution for Vascular Catheter–Site CareDiagnostic Study · 2002 · 607 citations
2Chlorhexidine vs Povidone-Iodine and Incidence of Catheter-Related InfectionsMeta-Analysis · 2026 · 2 citations
3Efficacy of chlorhexidine gluconate of different concentrations in preventing short peripheral catheter-related infections: A double-blind randomized controlled trial2025
4Comparison of Oligon catheters and chlorhexidine-impregnated sponges with standard multilumen central venous catheters for prevention of associated colonization and infections in intensive care unit patientsCohort Study · 2011 · 63 citations
5Chlorhexidine versus povidone-iodine alcoholic solutions in cardiac implantable electronic devices. The CHLOVIS randomized studyRCT · 2026

Chlorhexidine-Impregnated Dressing for Prevention of Colonization of Central Venous Catheters in Infants and Children2005
Effect of Skin Antiseptics Used in Peripheral Intravenous Catheter Application on Phlebitis Development: A Double- Blind Randomized Controlled Trial2024
Chlorhexidine-alcohol compared with povidone-iodine-alcohol skin antisepsis protocols in major cardiac surgery: a randomized clinical trial2024
Brachial-to-Radial Pressure Gradient in Critically Ill Patients Treated With Vasoactive Agents: A Prospective Observational StudyCritical Care Medicine · 2026
Scientific Output in Septic Shock According to Country Income and Gender: A Meta-Epidemiological StudyCritical Care Medicine · 2026

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