Key result
ACE2 deficiency in pregnant mice impaired gestational weight gain (30.3 vs 38.2 g; P<0.001) and restricted fetal growth compared to wild-type mice.
Why the study?
Does ACE2 deficiency impair gestational weight gain and fetal growth in a mouse model?
Population
ACE2 knockout (KO) and C57BL/6 (wild-type) mice, virgin and pregnant
Comparison
ACE2 deficiency (knockout model) vs C57BL/6 (wild-type) mice
Design
Preclinical
Follow-up
day 18 of gestation
Authors
Loading...
Hypothesis-generating for ACE2 in gestational growth; prospective human studies needed before clinical consideration.
Does ACE2 deficiency impair gestational weight gain and fetal growth in a mouse model?
Absolute Event Rate: 30.3% vs 38.2%
p-value: p=<0.001
ACE2 deficiency in pregnancy is associated with elevated placenta Ang II levels, impaired gestational weight gain, and restricted fetal growth in a mouse model.
Bharadwaj et al. (2011) studied Pregnancy. ACE2 deficiency (ACE2 knockout) vs. C57BL/6 (wild-type) mice was evaluated on Gestational body weight gain (p=<0.001). ACE2 deficiency in pregnant mice impaired gestational weight gain (30.3 vs 38.2 g; P<0.001) and restricted fetal growth compared to wild-type mice.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: