Key result
Severe nonalcoholic fatty liver disease was independently associated with a significantly increased risk of subclinical cerebro-cardiovascular atherosclerosis compared to normal controls (OR 2.04).
Why the study?
Is nonalcoholic fatty liver disease severity associated with subclinical cerebro-cardiovascular atherosclerosis in Korean men?
Cross-Sectional (n=1,652)
No
Is nonalcoholic fatty liver disease severity associated with subclinical cerebro-cardiovascular atherosclerosis in Korean men?
Odds Ratio: 2.04 (95% CI 1.44–2.89)
Absolute Event Rate: 47.9% vs 24.5%
p-value: p=0.001
Severity of nonalcoholic fatty liver disease on ultrasound is independently associated with subclinical cerebro-cardiovascular atherosclerosis in Korean men.
Severe NAFLD associated with higher subclinical CCVA risk; hypothesis-generating and requires prospective confirmation before practice change.
BACKGROUND: No studies have reported the relationship between nonalcoholic fatty liver disease (NAFLD) and concurrent cerebral artery and coronary artery atherosclerosis simultaneously. We aimed at determining whether NAFLD, as assessed by ultrasound, is associated with subclinical cerebro-cardio vascular atherosclerosis (CCVA) by multidetector-row computed tomography (MDCT), and high resolution-magnetic resonance angiography (HR-MRA). This cross-sectional study included men in the general Korean population aged 20-70 years. RESULTS: A total of 1,652 men participated in the study (normal, n = 835; mild-to-moderate NAFLD, n = 512; severe NAFLD, n = 305). The risk of subclinical CCVA was positively associated with age (odds ratio [OR] 1.068; 1.054-1.081, p < 0.001), body mass index (OR 1.120; 1.08 0-1.162, p < 0.001), hepatic enzyme levels (OR 1.012; 1.001-1.023, p = 0.027; OR 1.006; 1.001-1.012, p = 0.036), fasting glucose (OR 1.021; 1.015-1.027, p < 0.001), triglycerides (OR 1.002; 1.000-1.003, p = 0.016), hypertension (OR 2.836; 2.268-3.546, p < 0.001), and diabetes (OR 2.911; 2.137-3.964, p < 0.001). Also, high-density lipoprotein cholesterol was inversely associated with subclinical CCVA (OR 0.974; 0.965-0.982, p < 0.001). Compared with normal controls, the OR for subclinical CCVA after full adjustment was 1.46 in the mild-to-moderate NAFLD group (95% confidence interval [CI]: 1.10 to 1.93) and 2.04 in the severe NAFLD group (95% CI: 1.44 to 2.89). CONCLUSIONS: Our data show that NAFLD is common among Korean men, and NAFLD severity on ultrasonography is associated with subclinical CCVA, as assessed by MDCT, and HR-MRA.
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Lee et al. (2018) conducted a cross-sectional in Nonalcoholic fatty liver disease (NAFLD) (n=1,652). Severe nonalcoholic fatty liver disease (NAFLD) vs. Normal controls (no NAFLD) was evaluated on Subclinical cerebro-cardiovascular atherosclerosis (CCVA) (OR 2.04, 95% CI 1.44 to 2.89, p=0.001). Severe nonalcoholic fatty liver disease was independently associated with a significantly increased risk of subclinical cerebro-cardiovascular atherosclerosis compared to normal controls (OR 2.04).
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