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April 10, 2014Heart

Non-alcoholic fatty liver disease, metabolic syndrome and subclinical cardiovascular changes in the general population

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Why the study?

Does non-alcoholic fatty liver disease independently contribute to subclinical cardiovascular changes in the general population?

Population

1886 participants without known cardiovascular disease from the Korean Genome Epidemiology Study

Comparison

Presence of non-alcoholic fatty liver disease… vs Absence of NAFLD and MetS

Design

Cross-sectional

Authors

NKNan Hee KimJPJuri ParkSKSeong Hwan Kim

Discussion

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Overview

NAFLD independently associated with subclinical diastolic dysfunction and arterial stiffness; extends cross-sectional evidence but leaves causal and clinical implications open.

Structured PICO

Does non-alcoholic fatty liver disease independently contribute to subclinical cardiovascular changes in the general population?

P
Population
1886 participants without known cardiovascular disease from the Korean Genome Epidemiology Study
I
Intervention
Presence of non-alcoholic fatty liver disease (NAFLD) and/or metabolic syndrome (MetS)
C
Comparator
Absence of NAFLD and MetS
O
Outcome
Changes in cardiovascular structure and function assessed by tissue Doppler imaging (TDI) echocardiography, carotid ultrasound (CIMT), and brachial-ankle pulse wave velocity (baPWV)surrogate

NAFLD is associated with early subclinical alterations in cardiovascular function and arterial stiffness, independent of metabolic syndrome and established risk factors.

Cite This Study

Kim et al. (2014) studied this question.

synapsesocial.com/papers/6a76b60cee59ab58d3f6bf7bhttps://doi.org/10.1136/heartjnl-2013-305099
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased arterial stiffness in nonalcoholic fatty liver disease: the Cardio-GOOSE study2010 · 117 citations
  2. 2Endothelial dysfunction and cardiovascular risk profile in nonalcoholic fatty liver disease†2005 · 635 citations
  3. 3Nonalcoholic Fatty Liver Disease Is Associated With Left Ventricular Diastolic Dysfunction in Patients With Type 2 Diabetes2011 · 185 citations
  4. 4Hepatic Steatosis and Subclinical Cardiovascular Disease in a Cohort Enriched for Type 2 Diabetes: The Diabetes Heart Study2008 · 189 citations
  5. 5Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver2007 · 209 citations