Key result
Acute myeloid leukemia was associated with a 7.5% 10-year cumulative incidence of congestive heart failure, compared to 1.7% in children with acute lymphoblastic leukemia.
Why the study?
What is the incidence and what are the risk factors for congestive heart failure in children with acute leukemia?
Population
2053 children with first primary acute lymphoblastic leukemia and acute myeloid leukemia diagnosed 1992–2010…
Design
Cohort
Follow-up
10 years
Authors
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Low 10-year CHF incidence after anthracyclines in ALL versus AML may inform risk stratification; hypothesis-generating and requires prospective confirmation.
Cohort (n=2,053)
Yes
What is the incidence and what are the risk factors for congestive heart failure in children with acute leukemia?
Absolute Event Rate: 7.5% vs 1.7%
The 10-year cumulative incidence of congestive heart failure is 1.7% in pediatric ALL and 7.5% in pediatric AML, with risk factors including irradiation and anthracycline exposure.
Chellapandian et al. (2018) conducted a cohort in Acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) (n=2,053). Acute myeloid leukemia (AML) vs. Acute lymphoblastic leukemia (ALL) was evaluated on Congestive heart failure (CHF). Acute myeloid leukemia was associated with a 7.5% 10-year cumulative incidence of congestive heart failure, compared to 1.7% in children with acute lymphoblastic leukemia.
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