Neuro-molecular mediators of yoga intervention in females with prediabetes: A randomized controlled trial

Type 2 diabetes (T2D) is primarily a lifestyle-related disorder, which can be controlled by early detection of high-risk individuals with diabetes. It will be beneficial to halt the onset of diabetes by adopting lifestyle modification tools such as Yoga. The present research work emphasizes upon detecting the high-risk individual for diabetes through the Indian Diabetes Risk Score (IDRS). This manuscript addresses an important gap in lifestyle intervention research by highlighting the role of non-glycemic pathways in prediabetes management. Beyond conventional glucose regulation, the findings underscore how yoga-based interventions may influence broader metabolic, psychological, and cognitive domains that are critical in delaying or preventing disease progression. The study carries meaningful implications for preventive healthcare policy and practice. The findings also lay a strong scientific foundation for future longitudinal and mechanistic investigations into the durability of yoga's effects on metabolic regulation, stress resilience, and cognitive health, thereby advancing the evidence base for holistic approaches to chronic disease prevention.