Key result
Transdermal delivery of nitrates for congestive heart failure has been associated with disappointing 24-hour hemodynamics and rapid development of tolerance.
Why the study?
Do transdermal nitrates improve hemodynamics without tolerance in patients with severe congestive heart failure?
Do transdermal nitrates improve hemodynamics without tolerance in patients with severe congestive heart failure?
Transdermal delivery of nitrates in CHF may be limited by disappointing 24-hour hemodynamics and the rapid development of tolerance.
Caution advised with transdermal nitrates in severe CHF due to tolerance; leaves open optimal long-term dosing strategies.
Vasodilator therapy is an accepted mode of treating patients with severe congestive heart failure (CHF). Nitrates have a predominantly beneficial effect on preload, but also afterload may be beneficially modulated with higher doses. There is some evidence that long-term treatment with isosorbide dinitrate is beneficial in patients with CHF. By contrast, recent reports of 24 hour hemodynamics following transdermal delivery seem disappointing and rapid development of tolerance has been observed.
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Andreas Sjögren (1986) conducted a review in Congestive heart failure (CHF). Transdermal nitrates was evaluated. Transdermal delivery of nitrates for congestive heart failure has been associated with disappointing 24-hour hemodynamics and rapid development of tolerance.
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