Key result
Adipose tissue-derived exosomes play a critical role in mediating intercellular and interorgan communication, contributing to the pathogenesis of metabolic disorders such as obesity and diabetes.
Why the study?
Adipose tissue dysfunction leads to severe metabolic disorders, and accumulating evidence shows adipose tissue-derived exosomes mediate inter-tissue communication and contribute to metabolic disturbances.
This review highlights the emerging role of adipose tissue-derived exosomes in mediating metabolic disorders and discusses current obstacles in exosome-based therapies.
Answers are grounded in this paper and cite their sources.
Does not yet support exosome-targeted therapies in practice; extends mechanistic insights but leaves causality and translation open.
Adipose tissues perform physiological functions such as energy storage and endocrine, whose dysfunction will lead to severe metabolic disorders. Accumulating evidences show that exosomes can meditate communications between different tissues by transporting nucleic acids, proteins and other biological factors. More importantly, exosomes secreted by adipose tissue function as critical contributing factors that elucidate specific mechanisms in metabolic disturbance such as obesity, adipose inflammation and diabetes etc. Adipose tissue is the major source of circulating exosomal miRNAs. miRNA secreted from adipose tissues not only altered in patients with metabolic disease, but also result in an increase in metabolic organ talk. Here we have reviewed the latest progress on the role of adipose tissue derived exosomes roles in metabolic disorders. Moreover, the current obstacles hindering exosome-based therapeutic strategies have also been discussed.
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Mei et al. (2022) conducted a review in Metabolic diseases (obesity, diabetes, adipose inflammation). Adipose tissue-derived exosomes was evaluated. Adipose tissue-derived exosomes play a critical role in mediating intercellular and interorgan communication, contributing to the pathogenesis of metabolic disorders such as obesity and diabetes.
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