What question did this study set out to answer?

This study aims to assess how dopamine affects hemodynamics in dogs, particularly through the lens of alpha adrenergic blockade.

June 1, 1966Circulation Research

Hemodynamic Effects of Dopamine in the Dog Before and After Alpha Adrenergic Blockade

Q: What is the clinical evidence from this study?

Study design: Other. Intervention: Dopamine with alpha adrenergic blockade (phentolamine and phenoxybenzamine) vs. Dopamine before alpha adrenergic blockade. Primary outcome: Systemic hemodynamics, renal and femoral blood flows.

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Key result

Dopamine infused at 3 to 6 µg/kg/min after alpha adrenergic blockade in dogs unmasked a mild depressor effect of 10 to 25 mm Hg, while increasing cardiac output and renal blood flow.

Authors

JMJOHN L. MCNOYEmory University LGLeon I. GoldbergUniversity of Michigan

Discussion

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Implication

Animal data on dopamine's dual vascular actions warrant caution in human extrapolation; leaves open receptor mapping in clinical shock.

Key Points

This study aims to assess how dopamine affects hemodynamics in dogs, particularly through the lens of alpha adrenergic blockade.
Administered dopamine intravenously at nonpressor doses (3 to 6 µg/kg/min).
Simultaneously measured renal and femoral blood flows before and after phentolamine and phenoxybenzamine administration.
Evaluated systemic hemodynamics to understand the effects of alpha adrenergic antagonism.
Dopamine caused a modest drop in blood pressure ranging from 10 to 25 mm Hg.
Increased renal blood flow remained stable before and after alpha adrenergic block, while decreasing renal vascular resistance occurred post-block.
Femoral blood flow reduced after alpha blockade due to blood pressure depression, with no changes in femoral vascular resistance.

PICO

Intervention / Comparator

Dopamine with alpha adrenergic blockade (phentolamine and phenoxybenzamine) vs Dopamine before alpha adrenergic blockade (3 to 6 µg/kg/min)

Primary Outcome

Systemic hemodynamics, renal and femoral blood flows

Cite This Study

MCNOY et al. (1966) studied this question. Dopamine with alpha adrenergic blockade (phentolamine and phenoxybenzamine) vs. Dopamine before alpha adrenergic blockade was evaluated on Systemic hemodynamics, renal and femoral blood flows. Dopamine infused at 3 to 6 µg/kg/min after alpha adrenergic blockade in dogs unmasked a mild depressor effect of 10 to 25 mm Hg, while increasing cardiac output and renal blood flow.

synapsesocial.com/papers/6a62922355b722589b02a428 https://doi.org/10.1161/01.res.18.s6.i-110

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Hemodynamic Effects of Dopamine in the Dog Before and After Alpha Adrenergic Blockade

Discussion

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Implication

Key Points

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Cite This Study

Hemodynamic Effects of Dopamine in the Dog Before and After Alpha Adrenergic Blockade

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

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