Key result
Dopamine produces species-dependent vascular effects, causing depressor responses in rabbits and pressor responses in dogs.
Why the study?
The effect of dopamine on peripheral vasculature varies by species and remains incompletely characterized in rats.
Answers are grounded in this paper and cite their sources.
Species-specific dopamine vascular responses preclude animal-to-human extrapolation; leaves open targeted human validation studies.
Many investigators have reported that the effect of dopamine on the peripheral vasculature apparently varies and is dependent on the species. Holtz and Credner (1) observed that dopamine produced depressor effects in blood pressure of guinea pigs and rabbits while pressor effects were produced in cats and dogs. In the anesthetized cat and dog, dopamine causes vasodilatations in the superior and inferior mesenteric, gastric, and renal arteries and vasoconstrictions in the hepatic and splenic arteries (2, 3).
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Aihara et al. (1972) studied this question. Dopamine was evaluated. Dopamine produces species-dependent effects on the peripheral vasculature, causing depressor effects in guinea pigs and rabbits and pressor effects in cats and dogs.
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