Why the study?
Does local application of dopamine induce biphasic responses in rat pial arterioles?
Population
Anaesthetized male and female rats (pial arterioles 20-40 micrometer i.d.)
Comparison
Local perivascular application of dopamine vs Different doses of dopamine (low vs high)
Design
Preclinical
Authors
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Biphasic dopamine responses in rat pial arterioles do not inform clinical dosing; leaves open translation to human cerebral autoregulation.
Does local application of dopamine induce biphasic responses in rat pial arterioles?
Dopamine exhibits a biphasic effect on rat pial arterioles, causing vasodilation at low physiological doses and vasoconstriction at higher doses, suggesting a role in local cerebral blood flow regulation.
Altura et al. (1980) studied this question.
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