Potential Role of Autoantibodies Belonging to the Immunoglobulin G-3 Subclass in Cardiac Dysfunction Among Patients With Dilated Cardiomyopathy
Key result
Immunoadsorption with anti-IgG significantly increased cardiac index compared to protein A (3.0 vs 2.2 L/min/m2; P<0.01) and effectively eliminated IgG-3 autoantibodies in patients with DCM.
Why the study?
Does immunoadsorption with anti-IgG improve hemodynamics and LVEF compared to protein A immunoadsorption in patients with dilated cardiomyopathy?
Population
18 patients with dilated cardiomyopathy (DCM) and left ventricular ejection fraction <30%
Comparison
Immunoadsorption with anti-IgG, performed in 4… vs Immunoadsorption with protein A, performed in 4…
Design
Case-control
Follow-up
3 months
Authors
Discussion
Loading...
Member takes
Implication
May improve hemodynamics in DCM; leaves open superiority over protein A pending randomized trials.
Study Design
Type
Case-Control (n=18)
Structured PICO
Does immunoadsorption with anti-IgG improve hemodynamics and LVEF compared to protein A immunoadsorption in patients with dilated cardiomyopathy?
P
Population
18 patients with dilated cardiomyopathy and left ventricular ejection fraction <30% undergoing immunoadsorption over 3 months.
E
Exposure
Immunoadsorption with anti-IgG (removes all IgG subclasses), performed in 4 courses at 1-month intervals until month 3
C
Comparator
Immunoadsorption with protein A (low affinity to IgG-3), performed in 4 courses at 1-month intervals until month 3
O
Outcome
Changes in hemodynamics (cardiac index) and left ventricular ejection fractionsurrogate
Main Result
Absolute Event Rate: 3% vs 2.2%
p-value: p=<0.01
Removal of IgG-3 subclass autoantibodies via anti-IgG immunoadsorption significantly improves cardiac index and LVEF in patients with dilated cardiomyopathy compared to protein A immunoadsorption.
Cite This Study
Staudt et al. (2002) conducted a case-control in Dilated cardiomyopathy (DCM) (n=18). Immunoadsorption with anti-IgG vs. Immunoadsorption with protein A was evaluated on Cardiac index at 3 months (p=<0.01). Immunoadsorption with anti-IgG significantly increased cardiac index compared to protein A (3.0 vs 2.2 L/min/m2; P<0.01) and effectively eliminated IgG-3 autoantibodies in patients with DCM.