Why the study?
Does immunoadsorption therapy with IgG substitution improve LVEF and reduce cardiodepressant antibodies in patients with dilated cardiomyopathy?
Population
17 patients with dilated cardiomyopathy (DCM)
Design
Cohort
Follow-up
up to 12 months
Authors
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May support immunoadsorption for LVEF gains in antibody-positive DCM; leaves open randomized confirmation before practice change.
Does immunoadsorption therapy with IgG substitution improve LVEF and reduce cardiodepressant antibodies in patients with dilated cardiomyopathy?
Immunoadsorption with IgG substitution in DCM patients with cardiodepressant antibodies leads to long-term improvement in LVEF and reduction in negative inotropic antibodies, though antibodies may begin to re-increase by 12 months.
Trimpert et al. (2010) studied this question.
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