Takayasu’s arteritis: a relevant problem in modern rheumatology (a literature review)

Takayasu’s arteritis is a rare chronic large-vessel vasculitis that predominantly affects the aorta, its major branches and pulmonary arteries. The exact occurrence rate of this pathology is unknown. However, it has been found that the disease is registered in 2.6 people per 1 million of the population in Russia, more oft en in young females. As with all rheumatic diseases, the issues of pathogenesis and therapy of non-specific aortoarteritis remain open. The complexity of pathogenetic reactions appears to be a problem for early diagnosis and selection of the correct therapy. Th is review covers the issues of pathogenesis and modern pharmacotherapy: tumor necrosis factors, pharmacotherapy and genetically engineered drugs. The review was written based on analysis of scientific literature. The eLIBRARY.RU, Cyberleninka, Pub Med, Cochrane Library databases were searched for materials published within the period of 2002-2021 with an emphasis on the past 5-10 years for the following keywords: Takayasu arteries, nonspecific aortroartery, systemic vasculitis, rheumatological diseases