Leaflet remodelling in functional mitral valve regurgitation: characteristics, determinants, and relation to regurgitation severity
Key result
Insufficient mitral valve leaflet remodelling (coaptation/overall MV leaflet area ratio ≤0.24) was independently associated with severe functional mitral regurgitation (OR 70.0; 95% CI 11.7-419.9; P<0.001).
Population
76 subjects, including 30 patients with functional mitral regurgitation ≥ grade 3, 24 patients with FMR <…
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
May refine FMR severity assessment; leaves open prospective validation for risk stratification or therapy guidance.
Study Design
Type
Observational (n=76)
Structured PICO
P
Population
76 subjects including 30 patients with FMR ≥ grade 3, 24 with FMR < grade 3, and 22 controls with normal mitral valves evaluated by 3D transoesophageal echocardiography.
C
Comparator
Controls with normal mitral valves and patients with FMR < grade 3
O
Outcome
Mitral leaflet remodelling characteristics (overall MV leaflet area) and its relation to FMR severitysurrogate
Main Result
Odds Ratio: 70 (95% CI 11.7–419.9)
p-value: p=<0.001
Insufficient mitral valve leaflet remodelling relative to annular and left ventricular changes is strongly associated with severe functional mitral regurgitation.
Cite This Study
Debonnaire et al. (2014) conducted an observational in Functional mitral valve regurgitation (FMR) (n=76). Insufficient leaflet remodelling (coaptation/overall MV leaflet area ratio ≤0.24) vs. Sufficient leaflet remodelling (ratio >0.24) was evaluated on FMR ≥ grade 3 (OR 70.0, 95% CI 11.7-419.9, p=<0.001). Insufficient mitral valve leaflet remodelling (coaptation/overall MV leaflet area ratio ≤0.24) was independently associated with severe functional mitral regurgitation (OR 70.0; 95% CI 11.7-419.9; P<0.001).