Key result
Diabetes linked to ~2.7-fold higher odds of diastolic dysfunction in Hispanic adults.
Why the study?
Does diabetes mellitus increase the risk of left ventricular diastolic dysfunction in a Hispanic patient population?
Cross-Sectional (n=129)
No
Does diabetes mellitus increase the risk of left ventricular diastolic dysfunction in a Hispanic patient population?
This study highlights a high 67.4% prevalence of diastolic dysfunction in a referred Hispanic cohort and identifies diabetes, older age, and chronic kidney disease as strong independent predictors.
Answers are grounded in this paper and cite their sources.
May inform ethnic-specific risk stratification in Hispanics; extends prior associations but leaves open prospective validation.
Minimal data exist on attributes of diastolic dysfunction in the Hispanic population. The purpose of this study was to evaluate the prevalence and predictors of diastolic dysfunction in a Hispanic patient population. We performed a retrospective review of 166 consecutive echocardiograms in a southwestern Texas Hospital that caters to a large Hispanic patient population. We identified all echocardiograms that met criteria for diastolic dysfunction and assessed baseline demographics and comorbidities in the cohort of Hispanic patients. A multivariate analysis was performed to identify the independent predictors of diastolic dysfunction. A total of 129 out of 166 patients (77.8%) were of Hispanic origin. Out of the 129 patients, 87 (67.4%) had some degree of diastolic dysfunction in this population suggesting a high prevalence in the study cohort. In the diastolic dysfunction group, the mean age was 64.5 ± 13.9, 37% were male and 63% female, 78% had diabetes, 85% had hypertension, and 49% had some degree of renal insufficiency (stages 3-5). A logistic multivariate analysis showed that diabetes was an independent predictor of diastolic dysfunction with odds ratio of 2.69 (95% confidence interval [CI], 1.06-6.28; p = 0.038). Similarly age (per year increase) and chronic kidney disease were independent predictors of diastolic dysfunction. We demonstrated that older age, presence of diabetes, and renal dysfunction are independent predictors of diastolic dysfunction in the Hispanic patient population. Strategies geared toward reducing diabetes and preventing renal dysfunction are likely to decrease prevalence of diastolic dysfunction and heart failure in this community.
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Castro et al. (2013) conducted a cross-sectional in Left Ventricular Diastolic Dysfunction (n=129). Diabetes mellitus vs. Absence of diabetes mellitus was evaluated on Presence of left ventricular diastolic dysfunction (OR 2.69, 95% CI 1.06-6.28, p=0.038). Diabetes mellitus, along with older age and chronic kidney disease, was an independent predictor of diastolic dysfunction in the Hispanic population, increasing the odds by 2.69-fold.
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