Key result
Female carriers of X-linked Duchenne muscular dystrophy had a significantly greater algebraic sum of the R and S waves in the V(1) lead compared with normal women.
Why the study?
Is the algebraic sum of the R and S waves in the V(1) lead greater in female carriers of Duchenne muscular dystrophy compared to normal women?
Population
Female carriers of X-linked Duchenne muscular dystrophy, women with limb-girdle muscular dystrophy, and…
Comparison
Electrocardiogram (ECG) evaluation vs Normal women of comparable age and women with…
Design
Cross-sectional
Authors
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May suggest cardiomyopathy risk in DMD carriers; leaves open need for prospective validation.
Observational
Is the algebraic sum of the R and S waves in the V(1) lead greater in female carriers of Duchenne muscular dystrophy compared to normal women?
Female carriers of Duchenne muscular dystrophy exhibit specific ECG abnormalities (greater R-S sum in V1) that may indicate latent cardiomyopathy.
Alan E H Emery (1969) conducted an observational in Female carriers of X-linked Duchenne muscular dystrophy. Carrier status of X-linked Duchenne muscular dystrophy vs. Normal women of comparable age and women with limb-girdle muscular dystrophy was evaluated on Algebraic sum of the R and S waves (R-S) in the V(1) lead of the electrocardiogram. Female carriers of X-linked Duchenne muscular dystrophy had a significantly greater algebraic sum of the R and S waves in the V(1) lead compared with normal women.
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