Why the study?
Do carriers of Duchenne muscular dystrophy have specific electrocardiographic abnormalities compared to normal women?
Do carriers of Duchenne muscular dystrophy have specific electrocardiographic abnormalities compared to normal women?
Specific electrocardiographic parameters, particularly the R/S ratio in lead V2, are significantly altered in carriers of Duchenne muscular dystrophy and can be incorporated into probability calculations to determine carrier risk.
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May aid ECG screening for Duchenne muscular dystrophy carriers; leaves open validation in prospective studies.
Electrocardiographic (ECG) abnormalities characteristic of Duchenne muscular dystrophy (tall R waves in the right precordial leads and deep Q waves in the lateral chest leads) are rarely observed in carriers, but Emery (1969) found that the (R-S) amplitude sum in lead V1 was significantly greater in carriers than in age-matched controls. In a prospective single-blind study, we analyzed coded records from 11 carriers and 12 age-matched normal women for (R-S) amplitude sums and R/S ratios in leads V1 and V2. Values in carriers were significantly greater for all these characteristics, discrimination being most marked for R/S in V2 (p less than 0.01). This was confirmed in a further retrospective study, comparing records from 18 carriers with 100 normal ECGs from women of the same age range. Density functions for (R-S) in V1 and the R/S ratio in V2 derived from carrier and normal population can be incorporated into probability calculations to determine risk of carrier status.
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Lane et al. (1980) studied this question.
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