Key result
Increased left ventricular mass index was an independent risk factor for sudden cardiac death in asymptomatic patients with mild to moderate aortic stenosis (HR 1.20; 95% CI 1.10-1.32; P<0.001).
Why the study?
The incidence and potential risk factors of sudden cardiac death in asymptomatic patients with aortic stenosis remained to be assessed.
What is the incidence and what are the risk factors for sudden cardiac death in asymptomatic patients with mild to moderate aortic stenosis?
Cohort (n=1,849)
What is the incidence and what are the risk factors for sudden cardiac death in asymptomatic patients with mild to moderate aortic stenosis?
Hazard Ratio: 1.2 (95% CI 1.1–1.32)
p-value: p=<0.001
Sudden cardiac death in asymptomatic mild to moderate aortic stenosis is rare (0.39%/year) and is strongly associated with left ventricular hypertrophy rather than the severity of the stenosis.
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Supports LVMI incorporation into SCD risk stratification for mild-moderate AS; leaves open whether LVMI reduction improves outcomes.
Minners et al. (2020) conducted a cohort in Asymptomatic aortic stenosis (n=1,849). Increased left ventricular mass index (LVMI) was evaluated on Sudden cardiac death (SCD) (HR 1.20, 95% CI 1.10 to 1.32, p=<0.001). Increased left ventricular mass index was an independent risk factor for sudden cardiac death in asymptomatic patients with mild to moderate aortic stenosis (HR 1.20; 95% CI 1.10-1.32; P<0.001).
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