Sudden Death in Patients With Severe Aortic Stenosis: Observations From the CURRENT AS Registry
Key result
Symptomatic severe aortic stenosis is linked to ~28% higher 5-year sudden death risk versus asymptomatic patients.
- P<0.001
- n=3,815
Why the study?
The annual incidence of sudden death in asymptomatic patients with severe aortic stenosis is reported to be low, and data on risk factors for sudden death in severe AS patients are limited.
Population
3815 consecutive patients with severe AS enrolled in the CURRENT AS registry
Comparison
Symptomatic vs asymptomatic patients with severe AS
Design
Cohort study
Follow-up
Median 1334 days
Authors
Discussion
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Member takes
Implication
Supports closer surveillance of symptomatic severe AS; leaves open whether risk-stratified earlier intervention reduces sudden death in asymptomatic patients.
Study Design
Type
Cohort (n=3,815)
Structured PICO
P
Population
3,815 consecutive patients with severe aortic stenosis (mean age 78 years, 62% female) followed for a median of 1334 days.
O
Outcome
Incidence and risk factors of sudden deathhard clinical
Main Result
Absolute Event Rate: 9.2% vs 7.2%
p-value: p=<0.001
The incidence of sudden death in asymptomatic patients with severe aortic stenosis is higher than previously reported (1.4%/year), and is strongly associated with hemodialysis, prior MI, low BMI, and specific echocardiographic markers.
Cite This Study
Taniguchi et al. (2018) conducted a cohort in Severe aortic stenosis (n=3,815). Symptomatic severe aortic stenosis vs. Asymptomatic severe aortic stenosis was evaluated on Cumulative 5-year incidence of sudden death (p=<0.001). Symptomatic severe aortic stenosis was associated with a higher 5-year incidence of sudden death compared to asymptomatic patients (9.2% vs 7.2%; P<0.001).