What is the clinical evidence from this study?

Study design: Other. Population: Type 1 diabetes with cardiomyopathy (n=140). Intervention: Water soluble curcumin derivative (NCD) vs. Diabetic control (vehicle). Primary outcome: Plasma glucose level (mg/dL) (p=<0.001).

What question did this study set out to answer?

This research aims to evaluate the effects of a novel water soluble curcumin derivative on signaling mechanisms in type 1 diabetes and related heart issues.

March 12, 2013Diabetology & Metabolic SyndromeOpen Access

Signaling mechanisms of a water soluble curcumin derivative in experimental type 1 diabetes with cardiomyopathy

Q: What are the key findings of this study?

A water-soluble curcumin derivative significantly decreased plasma glucose levels and improved left ventricular function in rats with experimental type 1 diabetes.

Q: What question did this study set out to answer?

This research aims to evaluate the effects of a novel water soluble curcumin derivative on signaling mechanisms in type 1 diabetes and related heart issues.

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Key result

A water-soluble curcumin derivative significantly decreased plasma glucose levels and improved left ventricular function in rats with experimental type 1 diabetes.

Why the study?

Does a water soluble curcumin derivative improve metabolic parameters and left ventricular function in a rat model of experimental type 1 diabetes with cardiomyopathy?

Population

Rats with experimental type 1 diabetes and cardiomyopathy

Comparison

Novel water soluble curcumin derivative given… vs Non-diabetic controls, untreated diabetic rats…

Design

Preclinical

Follow-up

45 days

Authors

MAMohamed Talaat Abdel AzizCairo University IIIbrahim Naguib El IbrashyCairo University DMDimitri P. MikhailidisThe Royal Free Hospital

Discussion

Member takes

Implication

Hypothesis-generating for NCD in diabetic hypertrophy; leaves open translation to human cardiomyopathy prevention.

Key Points

This research aims to evaluate the effects of a novel water soluble curcumin derivative on signaling mechanisms in type 1 diabetes and related heart issues.
Rats were divided into various treatment groups including controls, diabetic, and treatment with NCD and curcumin over 45 days.
Plasma glucose, insulin levels, and gene expressions related to cardiovascular function were assessed post-treatment.
The actions of the curcumin derivative were studied in relation to heme-oxygenase-1 gene expression.
NCD and curcumin significantly decreased plasma glucose and glycated hemoglobin while increasing insulin levels in diabetic rats.
The significantly elevated HO-1 expression and activity were observed in diabetic heart and pancreas tissues.
NCD outperformed pure curcumin in preventing diabetes-induced upregulation of cardiac biomarkers and improving left ventricular function.

Structured PICO

Does a water soluble curcumin derivative improve metabolic parameters and left ventricular function in a rat model of experimental type 1 diabetes with cardiomyopathy?

Population

140 adult rats with streptozotocin-induced type 1 diabetes, followed for 45 days to evaluate the effects of a water-soluble curcumin derivative.

Intervention

Novel water soluble curcumin derivative (NCD) given orally for 45 days

Comparator

Non-diabetic controls, untreated diabetic rats, diabetic rats receiving pure curcumin, diabetic rats receiving HO inhibitor (zinc protoporphyrin IX [ZnPP IX]), and diabetic rats receiving NCD and ZnPP IX

Outcome

Cardiac physiologic parameters, plasma glucose, insulin, glycated hemoglobin (GHb), HO-1 gene expression and HO activity, gene expression of p300, atrial natriuretic peptide (ANP), and myocyte enhancer factor 2 (MEF2A and MEF2C)surrogate

Main Result

Absolute Event Rate: 183% vs 307%

p-value: p=<0.001

A novel water-soluble curcumin derivative improves metabolic parameters and left ventricular function in a rat model of diabetic cardiomyopathy, potentially via HO-1 induction and p300 inhibition.

Limitations

High mortality rate (29.3%) among the experimental animals
Animal model findings may not directly translate to human diabetic cardiomyopathy

Cite This Study

Aziz et al. (2013) studied Type 1 diabetes with cardiomyopathy (n=140). Water soluble curcumin derivative (NCD) vs. Diabetic control (vehicle) was evaluated on Plasma glucose level (mg/dL) (p=<0.001). A water-soluble curcumin derivative significantly decreased plasma glucose levels and improved left ventricular function in rats with experimental type 1 diabetes.

synapsesocial.com/papers/6a62bb0c53a7dba88202bb89 https://doi.org/10.1186/1758-5996-5-13

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Signaling mechanisms of a water soluble curcumin derivative in experimental type 1 diabetes with cardiomyopathy

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Limitations

Cite This Study

Signaling mechanisms of a water soluble curcumin derivative in experimental type 1 diabetes with cardiomyopathy

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider