Key result
ADAR1 splice site variants efficiently edited the A site of 5-HT2CR pre-mRNA in vitro, while the D site was not an efficient substrate.
Population
Rat brain and in vitro models (5-HT2CR pre-mRNA)
Design
Preclinical
Authors
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Does not support clinical application; leaves open in vivo relevance of ADAR1 editing to 5-HT2CR signaling.
ADAR1 splice variants catalyze site-specific A-to-I editing of the serotonin-2C receptor pre-mRNA, with distinct roles for its double-stranded RNA binding motifs.
Liu et al. (1999) studied this question. ADAR1 splice site variants was evaluated on 5-HT2CR pre-mRNA editing (A-to-I nucleotide conversions). ADAR1 splice site variants efficiently edited the A site of 5-HT2CR pre-mRNA in vitro, while the D site was not an efficient substrate.
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