Key result
ADAR1-a, -b, and -c splice variants efficiently edited the R/G site and intron +60 hotspot of GluR-B pre-mRNA but exhibited little activity at the Q/R site.
Population
In vitro models and dissected regions of rat brain
Design
Preclinical
Authors
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ADAR1 splice variants show distinct editing activity; leaves open any cardiac RNA-editing roles or arrhythmia links.
Different splice-site variants of ADAR1 exhibit distinct site-specific RNA editing activities on GluR-B pre-mRNA.
Liu et al. (1999) studied this question. ADAR1 splice-site variants (ADAR1-a, -b, and -c) was evaluated on Editing of GluR-B pre-mRNA at Q/R and R/G sites and intron +60 hotspot. ADAR1-a, -b, and -c splice variants efficiently edited the R/G site and intron +60 hotspot of GluR-B pre-mRNA but exhibited little activity at the Q/R site.
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