Key result
Recombinant viruses in which the 3' portion of the cVDPV genome was replaced by the 3' half of the CA17 genome were viable and almost as neurovirulent as the cVDPV in transgenic mice.
Population
Transgenic mice expressing the poliovirus cellular receptor gene, and viral isolates
Comparison
Recombinant constructs combining genetic… vs Parental strains
Design
Preclinical
Authors
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Neurovirulence of CA17-cVDPV recombinants in mice is hypothesis-generating; leaves open 3' genome contributions to human pathogenicity.
Recombination between poliovirus vaccine strains and co-circulating coxsackieviruses can generate viable, pathogenic recombinants, providing a model for viral evolution and the emergence of vaccine-derived polioviruses.
Jégouic et al. (2009) studied Poliomyelitis / Vaccine-Derived Polioviruses. Poliovirus/CA17 recombinant viruses vs. Parental strains (Sabin 2, MAD04, CA17.67591) was evaluated on Neurovirulence (PD50) and viral replication. Recombinant viruses in which the 3' portion of the cVDPV genome was replaced by the 3' half of the CA17 genome were viable and almost as neurovirulent as the cVDPV in transgenic mice.
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