May 19, 2006Angewandte Chemie International Edition164 citationsOpen Access
View Full PaperBuilding Complex Glycopeptides: Development of a Cysteine‐Free Native Chemical Ligation Protocol
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Abstract
The missing link: Reiterative ligations based on non-cysteine and cysteine-based acyl acceptors have been used to prepare synthetic polypeptides and proteins with multiple sites of glycosylation. Highly complex positionally defined glycopolypeptides corresponding to single glycoforms can be formed from simple components.