Key result
Genomic analysis of a novel human parechovirus isolated from a child with diarrhea revealed a 7,305-nucleotide genome that represents a new genotype distinct from the 8 known types.
Case Report (n=1)
No
Identification and genomic characterization of a novel human parechovirus genotype from a child with diarrhea in China.
Novel HPeV genome from a Chinese child with diarrhea; extends viral diversity and leaves open its clinical role.
Human parechoviruses (HPeVs) belonging to the family Picornaviridae are widely spread pathogens among young children. We report the complete genome sequence of a novel HPeV isolated from the stool sample of a hospitalized child with diarrhea in China. The genome consists of 7,305 nucleotides, excluding the 3' poly(A) tail, and has an open reading frame that maps between nucleotide positions 675 and 7217 and encodes a 2,180-amino-acid polyprotein. The genome sequence of the virus was sufficiently distinct from the 8 known HPeV types. Phylogenetic analysis based on the complete genome indicated that the HPeV strain represents a new genotype.
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Wang et al. (2012) conducted a case report in Diarrhea (n=1). Novel Human Parechovirus was evaluated on Complete genome sequence and phylogenetic analysis. Genomic analysis of a novel human parechovirus isolated from a child with diarrhea revealed a 7,305-nucleotide genome that represents a new genotype distinct from the 8 known types.
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