Key result
Genomic sequencing of novel parechovirus CH-ZJ1 reveals likely recombination among HPeV1, HPeV3, and HPeV4.
Case Report (n=1)
The identification and sequencing of the novel HPeV strain CH-ZJ1 reveals natural recombination events among different human parechovirus strains.
Human parechoviruses (HPeVs) are a species in the Parechovirus genus of the Picornaviridae family. We report a complete genome sequence of a novel HPeV strain, CH-ZJ1, that was found in an infant with gastroenteritis in Zhenjiang City, China. The complete genome consists of 7,298 nucleotides (nt), excluding the 3' poly(A) tail; the open reading frame is mapped between nucleotide positions 654 and 7211 and encodes a 2,185-amino acid (aa) polyprotein. The phylogenetic tree obtained for the complete genome of this HPeV strain and the other HpeV strains available in GenBank indicated that CH-ZJ1 is intervenient between HpeV type 4 (HpeV4) and HpeV5. Phylogenetic analysis based on the 3D and VP1 genes reveals two incongruent trees. Recombination detection indicated that CH-ZJ1 might be a recombinant which was produced by more than one genomic recombination event that occurred among HPeV1, HPeV4, and HPeV3 strains.
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Sun et al. (2012) conducted a case report in Gastroenteritis (n=1). Genomic sequencing was evaluated on Complete genome sequence and phylogenetic analysis. Genomic sequencing of a novel human parechovirus strain (CH-ZJ1) from an infant with gastroenteritis revealed it is likely a recombinant produced by events among HPeV1, HPeV4, and HPeV3 strains.
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