Key result
Human parechovirus shows no clinical differences versus uninfected cases in pediatric acute gastroenteritis.
Cross-Sectional (n=322)
This study demonstrates the genetic diversity and recombination of human parechovirus circulating in children with acute gastroenteritis in Guangzhou, China.
HPeV recombination in young Chinese children may warrant surveillance; hypothesis-generating for clinical impact and transmission.
Human parechovirus (HPeV), a member of Picornaviridae family, is a widespread pathogen causing a wide spectrum of diseases. Like other picornaviruses, HPeV genome recombination has been detected. A total of 322 fecal samples were collected from children outpatients in Guangzhou, China, including 42 (13.0%, 42/322) HPeV-positive samples detected in most of the infected children less than two years old. Seven HPeV genotypes (HPeV1, HPeV3, HPeV4, HPeV5, HPeV6, HPeV8 and HPeV14) were detected, among which, HPeV14, a rare genotype, was reported for the first time in children with acute gastroenteritis in China. This study revealed recombination events in eight samples. Clinical profiles did not yield statistical significance between children with HPeV infection alone and cases without pathogens detected. In conclusion, this study demonstrated that HPeV circulated in Guangzhou, China is diverse genetically, which provided evidence of recombination in HPeV in China.
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Chen et al. (2014) conducted a cross-sectional in acute gastroenteritis (n=322). Human parechovirus (HPeV) infection vs. cases without pathogens detected was evaluated on Clinical profiles. Human parechovirus was present in 13.0% of pediatric outpatients with acute gastroenteritis, showing genetic diversity and recombination but no significant clinical differences versus uninfected cases.
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