Key result
Human parechovirus appears in 55% of acute diarrhea cases in young children, predominantly genotype HPeV1.
Cross-Sectional (n=300)
No
The study demonstrates a high prevalence of human parechovirus, predominantly genotype HPeV1, among young children hospitalized with acute diarrhea in Shanghai.
High HPeV detection in young children with diarrhea supports expanded testing; leaves open causal role and need for controlled studies.
Human parechoviruses (HPeVs) are widespread pathogens belonging to the Picornavirus family. The aim of the present study was to assess the prevalence and genetic diversity of HPeV in Shanghai, China, during a HPeV screening program in 2008 and 2009. Of 300 stool samples from children under the age of 5 years with acute diarrhea seen at Children's Hospital, Fudan University, Shanghai, China, 165 (55%) were HPeV-positive. The median age of infected children was 3 months. The prevalence of HPeV was high (57%) in infants up to 2 years old but dropped to 30.4% in children between 2 and 5 years old. The prevalence did not differ by sex. Infections were present throughout the year but peaked in July and August. The most predominant genotype was HPeV1. Of the 139 strains, 4 were found in 9 samples: HPeV4 (n = 4), HPeV5 (n = 1), HPeV6 (n = 1), and HPeV8 (n= 3). This study provided useful data on the epidemiology of HPeV infection by documenting the distribution of genotypes, age of infection, and seasonal patterns in Shanghai, China.
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Zhong et al. (2011) conducted a cross-sectional in Acute diarrhea (n=300). Human parechovirus (HPeV) was evaluated on HPeV positivity. Human parechovirus was detected in 55% of stool samples from children under 5 years old with acute diarrhea, with HPeV1 being the predominant genotype.
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