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September 16, 2009Journal of General Virology

Comprehensive full-length sequence analyses of human parechoviruses: diversity and recombination

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Key result

Genomic sequence analysis of 35 human parechoviruses revealed frequent recombination among HPeV1, -4, -5, and -6, whereas HPeV3 strains remained largely monophyletic across the genome.

Population

35 full-length genomic sequences of human parechoviruses, including 18 newly generated sequences of HPeV1…

Design

Preclinical

Authors

KBKimberley BenschopChildren's Mercy HospitalMVMichèl de VriesWesterdijk Fungal Biodiversity InstituteRMR. P. MinnaarAmsterdam UMC Location University of Amsterdam

Discussion

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Implication

Suggests type-specific evolutionary constraints in parechoviruses; leaves open implications for surveillance and vaccine strategies.

Structured PICO

P
Population
Analysis of 35 full-length genomic sequences of human parechoviruses collected over 14 years from The Netherlands to investigate viral evolution and recombination.
E
Exposure
Full-length genomic sequence analysis (phylogenetic and recombination analysis)
O
Outcome
Viral evolution, population dynamics, and recombination breakpoints

Genomic analysis of human parechoviruses reveals frequent recombination in HPeV1, -4, -5, and -6, but restricted recombination in HPeV3, suggesting different evolutionary dynamics.

Cite This Study

Benschop et al. (2009) studied Human parechovirus (n=35). Genomic sequence analysis was evaluated on Genetic diversity and recombination breakpoints. Genomic sequence analysis of 35 human parechoviruses revealed frequent recombination among HPeV1, -4, -5, and -6, whereas HPeV3 strains remained largely monophyletic across the genome.

synapsesocial.com/papers/6a896d8a0e4958e0bcf7c476https://doi.org/10.1099/vir.0.014670-0
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