Key result
Total bilirubin >14.3 mg/dl (OR 29.1; 95% CI 2.5-355.5; P=0.007) and concurrent myocarditis were significantly associated with fatality in neonates with enterovirus-induced hepatic necrosis.
Population
146 neonates with virus culture-confirmed nonpolio enterovirus infection
Design
Cohort
Authors
Loading...
May aid early identification of high-risk neonates; leaves open need for prospective validation before changing practice.
Cohort (n=146)
No
Odds Ratio: 29.1 (95% CI 2.5–355.5)
p-value: p=0.007
In neonates with enterovirus infection, concurrent myocarditis and high total bilirubin are strongly associated with fatal hepatic necrosis with coagulopathy.
Lin et al. (2003) conducted a cohort in Neonatal enterovirus infections (n=146). Total bilirubin >14.3 mg/dl vs. Total bilirubin ≤14.3 mg/dl was evaluated on Fatality from hepatic necrosis with coagulopathy (OR 29.1, 95% CI 2.5-355.5, p=0.007). Total bilirubin >14.3 mg/dl (OR 29.1; 95% CI 2.5-355.5; P=0.007) and concurrent myocarditis were significantly associated with fatality in neonates with enterovirus-induced hepatic necrosis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: