Key result
Blockade of Kv1.2 channels with TsTX-Kalpha increased depolarising after-potential amplitude, leading to aberrant action potentials and indicating they suppress terminal hyperexcitability.
Kv1.2 channels play a crucial presynaptic role in suppressing terminal hyperexcitability during the depolarising after-potential in rat synapses.
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Clarifies presynaptic Kv1.2 suppression of terminal hyperexcitability in vitro; leaves open in vivo roles and therapeutic relevance.
Dodson et al. (2003) studied this question. dendrotoxin-K (DTX-K) and tityustoxin-Kalpha (TsTX-Kalpha) was evaluated on presynaptic low threshold current and terminal excitability. Blockade of Kv1.2 channels with TsTX-Kalpha increased depolarising after-potential amplitude, leading to aberrant action potentials and indicating they suppress terminal hyperexcitability.
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