Key result
Kv2.1 channels localize at specific postsynaptic cholinergic and excitatory synapses in alpha-motoneurones.
Population
Rat spinal motoneurones and other spinal cord neurones
Design
Preclinical
Authors
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Suggests novel synaptic roles for Kv2.1 in motoneurons; leaves open translation to human motor disorders.
The strategic localization of Kv2.1 subunit-containing channels at specific postsynaptic sites in rat spinal motoneurones suggests additional roles beyond action potential repolarization.
Muennich et al. (2003) studied this question. Kv2.1 channel subunit distribution analysis was evaluated on Surface distribution and clustering of Kv2.1 subunit-containing channels in the cell membrane of alpha-motoneurones and other spinal cord neurones. Kv2.1 subunit-containing channels are strategically localized at specific postsynaptic sites, including cholinergic C-terminals and presumed excitatory S-type synapses in alpha-motoneurones.
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