The Kv2.1 C-terminal domain acts as an autonomous module that transfers phosphorylation-dependent clustering and cholinergic modulation to diverse potassium channels, providing a mechanism for dynamic regulation of neuronal excitability.
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May link cholinergic input to hippocampal excitability via Kv2.1; leaves open in vivo relevance and therapeutic translation.
Mohapatra et al. (2006) studied this question.
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