What does this research mean for the field?

The Kv2.1 cytoplasmic C-terminal domain acts as an autonomous module sufficient to transfer Kv2.1-like phosphorylation-dependent clustering, voltage-dependent activation, and cholinergic modulation to diverse Kv channels. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 11, 2006Journal of NeuroscienceOpen Access

The Kv2.1 C Terminus Can Autonomously Transfer Kv2.1-Like Phosphorylation-Dependent Localization, Voltage-Dependent Gating, and Muscarinic Modulation to Diverse Kv Channels

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Population

Cultured embryonic rat hippocampal neurons and recombinant Kv2.1 expressed in human embryonic kidney 293 and…

Comparison

Cholinergic stimulation or Ca2+ ionophore… vs Control conditions or pretreatment with…

Design

Preclinical, Blinded scoring for clustered or dispersed localization.

Authors

DMDurga P. MohapatraNational Institutes of Health JTJames S. TrimmerElectrophysiology

Discussion

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Implication

May link cholinergic input to hippocampal excitability via Kv2.1; leaves open in vivo relevance and therapeutic translation.

Structured PICO

Population

Cultured embryonic rat hippocampal neurons (from embryonic day 18/19 embryos) and recombinant Kv2.1 expressed in human embryonic kidney 293 (HEK293) and COS-1 cells.

Intervention

Cholinergic stimulation (100 µM carbachol for 15 min) or Ca2+ ionophore treatment (1 µM ionomycin for 10 min).

Comparator

Control conditions (no treatment) or pretreatment with calcineurin inhibitor FK520 (5 µM for 10 min).

Outcome

Kv2.1 phosphorylation state, clustering localization, and voltage-dependent gating properties.surrogate

The Kv2.1 C-terminal domain acts as an autonomous module that transfers phosphorylation-dependent clustering and cholinergic modulation to diverse potassium channels, providing a mechanism for dynamic regulation of neuronal excitability.

Cite This Study

Mohapatra et al. (2006) studied this question.

synapsesocial.com/papers/6a19dafa4b45427442ead10a https://doi.org/10.1523/jneurosci.4620-05.2006

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The Kv2.1 C Terminus Can Autonomously Transfer Kv2.1-Like Phosphorylation-Dependent Localization, Voltage-Dependent Gating, and Muscarinic Modulation to Diverse Kv Channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Kv2.1 C Terminus Can Autonomously Transfer Kv2.1-Like Phosphorylation-Dependent Localization, Voltage-Dependent Gating, and Muscarinic Modulation to Diverse Kv Channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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