Key result
Variable phosphorylation of the Kv2.1 potassium channel at multiple calcineurin-regulated sites allows graded activity-dependent regulation of channel gating and neuronal firing properties.
Population
Mammalian neurons / cell culture model expressing the Kv2.1 potassium channel
Comparison
Activity-dependent Kv2.1 dephosphorylation by… vs Resting state / wild-type Kv2.1
Design
Preclinical
Authors
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Hypothesis-generating for graded neuronal excitability control in models; leaves open translation to human cardiac ion channel regulation.
Variable phosphorylation of the Kv2.1 channel at multiple sites allows for graded, activity-dependent regulation of neuronal excitability.
Park et al. (2006) studied this question. Mutation of calcineurin-regulated phosphorylation sites was evaluated on Voltage-dependent activation and neuronal excitability. Variable phosphorylation of the Kv2.1 potassium channel at multiple calcineurin-regulated sites allows graded activity-dependent regulation of channel gating and neuronal firing properties.
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