Population
Mammalian neurons (in vivo seizure models, cultured hippocampal neurons, in vitro calcineurin digestion)
Comparison
Kainate-induced seizures, glutamate stimulation… vs Baseline/control conditions
Design
Preclinical
Authors
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Hypothesis-generating for activity biosensors in neurons; leaves open validation and cardiovascular translation in higher models.
S603 phosphorylation on Kv2.1 channels acts as a sensitive bidirectional biosensor of neuronal activity.
Misonou et al. (2006) studied this question.
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