Key result
Clustered Kv2.1 channels do not efficiently conduct K+ despite sensing membrane potential changes, whereas nonclustered channels are responsible for the high-threshold delayed rectifier K+ current.
Population
HEK293 cells expressing a tagged Kv2.1 construct (GFP-Kv2.1loopBAD)
Comparison
Cell-attached patch clamp and declustering via… vs Clustered vs. non-clustered Kv2.1 channels…
Design
Preclinical
Authors
Loading...
Clustered Kv2.1 may exert nonconducting signaling roles; leaves open relevance to cardiac excitability pending mammalian studies.
Clustered Kv2.1 channels on the cell surface are nonconducting but responsive to voltage changes, suggesting a unique role independent of K+ conductance.
O’Connell et al. (2010) studied this question. Cell surface location (clustered vs nonclustered Kv2.1 channels) vs. Clustered vs nonclustered was evaluated on K+ channel conductance and gating currents. Clustered Kv2.1 channels do not efficiently conduct K+ despite sensing membrane potential changes, whereas nonclustered channels are responsible for the high-threshold delayed rectifier K+ current.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: