Key result
Kv2.1 clusters are formed by sub-membrane cytoskeletal structures that limit the lateral diffusion of a sub-population of channels carrying specific C-terminus modifications.
Population
Neurons and transfected HEK cells
Design
Preclinical
Authors
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Requires validation in human cardiomyocytes; extends mechanistic observations on Kv2.1 but leaves clinical relevance open.
Kv2.1 channel clusters are formed by sub-membrane cytoskeletal structures that limit lateral diffusion of channels with specific C-terminus modifications.
Tamkun et al. (2007) studied this question. Single quantum dot (Qdot) tracking and FRAP was evaluated on Diffusion coefficients of GFP-labeled Kv2.1 channels. Kv2.1 clusters are formed by sub-membrane cytoskeletal structures that limit the lateral diffusion of a sub-population of channels carrying specific C-terminus modifications.
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