What does this research mean for the field?

The nonconducting state of Kv2.1 potassium channels is primarily determined by cell surface density rather than cluster localization, and the vast majority of native Kv2.1 channels in hippocampal neurons are nonconducting. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

January 16, 2013Journal of NeuroscienceOpen Access

Regulation of Kv2.1 K⁺Conductance by Cell Surface Channel Density

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Structured PICO

Population

Transfected HEK cells and cultured rat hippocampal neurons

Intervention

Varying cell surface density of Kv2.1 channels

Comparator

Different surface densities and Kv1.4 channels

Outcome

K(+) channel conductance measured by whole-cell voltage clampsurrogate

The nonconducting state of Kv2.1 channels depends primarily on surface density, supporting a nonconducting role for Kv2.1 in excitable tissues.

Discussion

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Implication

Channel density may silence Kv2.1 in vitro; leaves open physiological roles in native excitable tissues.

Cite This Study

Fox et al. (2013) studied this question.

synapsesocial.com/papers/6a19dafa4b45427442ead0fa https://doi.org/10.1523/jneurosci.3008-12.2013

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Regulation of Kv2.1 K⁺Conductance by Cell Surface Channel Density

Structured PICO

Discussion

Implication

Cite This Study

Regulation of Kv2.1 K⁺Conductance by Cell Surface Channel Density

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider