Key result
Trimethaphan-induced autonomic blockade prolonged the QTc interval in normal subjects (from 432 to 469 ms) and in patients with multiple system atrophy (from 448 to 463 ms).
Why the study?
Does ganglionic autonomic blockade with trimethaphan modulate the QT interval in normal subjects and patients with autonomic failure?
Population
27 subjects total: 10 normal volunteers, 9 patients with multiple system atrophy, and 8 patients with pure…
Comparison
Trimethaphan infusion at increasing doses vs Baseline measurements and cross-group comparisons
Design
Cohort
Authors
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Ganglionic blockade prolongs QTc; leaves open direct autonomic effects on repolarization independent of rate in small human studies.
Does ganglionic autonomic blockade with trimethaphan modulate the QT interval in normal subjects and patients with autonomic failure?
Absolute Event Rate: 469% vs 432%
Ganglionic autonomic blockade with trimethaphan prolongs the QT interval, demonstrating that baseline autonomic tone actively modulates ventricular repolarization.
Diedrich et al. (2002) studied Multiple system atrophy and pure autonomic failure (n=27). Trimethaphan vs. Baseline was evaluated on QTc interval. Trimethaphan-induced autonomic blockade prolonged the QTc interval in normal subjects (from 432 to 469 ms) and in patients with multiple system atrophy (from 448 to 463 ms).
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