Key result
Transgenic mice with cardiac Gsalpha overexpression exhibited elevated baseline heart rate (696 vs 568 bpm, P<.05) and mean arterial pressure (123 vs 103 mm Hg, P<.05) compared with wild-type mice.
Why the study?
Does cardiac Gsalpha overexpression alter autonomic cardiovascular control in mice?
Population
Conscious transgenic mice with cardiac-specific Gsalpha overexpression and age-matched wild-type control mice
Comparison
Cardiac-specific Gsalpha overexpression vs Age-matched wild-type (WT) control mice
Design
Preclinical
Authors
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Gsα overexpression may impair autonomic control in mice; leaves open relevance to human cardiomyopathy mechanisms.
Does cardiac Gsalpha overexpression alter autonomic cardiovascular control in mice?
Absolute Event Rate: 696% vs 568%
p-value: p=<.05
Cardiac-specific Gsalpha overexpression in mice leads to elevated baseline heart rate, increased arterial pressure, and depressed heart rate variability, which may be critical mechanisms contributing to the development of cardiomyopathy.
Uechi et al. (1998) studied Cardiomyopathy. Cardiac-specific Gsalpha overexpression vs. Age-matched wild-type (WT) control mice was evaluated on Baseline heart rate (bpm) (p=<.05). Transgenic mice with cardiac Gsalpha overexpression exhibited elevated baseline heart rate (696 vs 568 bpm, P<.05) and mean arterial pressure (123 vs 103 mm Hg, P<.05) compared with wild-type mice.
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